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Basic Science Team

General presentation

HP2's basic science, supervised by Pr. Diane Godin-Ribuot, is carried out on Jean Roget building 6th floors, on the Medicine-Pharmacology Faculty.

The team concentrates on the comprehension of hypoxic-conditions-linked physiopathological mechanisms, particularly on heart, vessels, metabolism, and, more recently, cancer.

Key publications

  • Arnaud C, Bouyon S, Recoquillon S, Brasseur S, Lemarié E, Briançon-Marjollet A, et al. Nonmuscle Myosin Light Chain Kinase: A Key Player in Intermittent Hypoxia-Induced Vascular Alterations. J Am Heart Assoc. 2018;7(3).
    PubMed Google Scholar BibTex
  • Morand J, Arnaud C, Pepin J-, Godin-Ribuot D. Chronic intermittent hypoxia promotes myocardial ischemia-related ventricular arrhythmias and sudden cardiac death. Sci Rep. 2018;8(1):2997.
    PubMed Google Scholar BibTex
  • Minoves M, Morand J, Perriot F, Chatard M, Gonthier B, Lemarié E, et al. An innovative intermittent hypoxia model in cell cultures allowing fast PO2 oscillations with minimal gas consumption. Am J Physiol, Cell Physiol. 2017:ajpcell.00098.2017.
    PubMed Google Scholar BibTex
  • Poulain L, Mathieu H, Thomas A, Borel A-, Remy C, Levy P, et al. Intermittent hypoxia-induced insulin resistance is associated with alterations in white fat distribution. Sci Rep. 2017;7(1):11180.
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  • Thomas A, Belaidi E, Moulin S, Horman S, van der Zon GC, Viollet B, et al. Chronic Intermittent Hypoxia Impairs Insulin Sensitivity but Improves Whole-Body Glucose Tolerance by Activating Skeletal Muscle AMPK. Diabetes. 2017.
    PubMed Google Scholar BibTex


Claire Arnaud (claire[dot]arnaud[at]univ-grenoble-alpes[dot]fr)

Henri Benoit (henri[dot]benoit[at]univ-grenoble-alpes[dot]fr)

Sophie Bouyon (sophie[dot]bouyon[at]univ-grenoble-alpes[dot]fr)

Anne Briançon-Marjollet (anne[dot]briancon-marjollet[at]univ-grenoble-alpes[dot]fr)

Gilles Faury (gilles[dot]faury[at]univ-grenoble-alpes[dot]fr)

Sylvain Kotzki (sylvain[dot]kotzki[at]univ-grenoble-alpes[dot]fr)

Emeline Mercier (emeline[dot]lemarie[at]univ-grenoble-alpes[dot]fr)

Christophe Ribuot (christophe[dot]ribuot[at]univ-grenoble-alpes[dot]fr)

Guillaume Vial (guillaume[dot]vial[at]inserm[dot]fr)


Pr. Diane Godin-Ribuot, manager (diane[dot]ribuot[at]univ-grenoble-alpes[dot]fr)

Submitted on December 20, 2023

Updated on December 20, 2023